Injectafer contains the active drug ferric carboxymaltose. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Cancer patients who have anemia and are taking an ESA. Venofer pregnancy and breastfeeding warnings. You will be watched closely by your doctor for 30 minutes after each dose. Sharing this information can help you avoid potential interactions. I'm contemplating getting infusions again but I've always been a bit worried that they could cause issues in the long run. Iron sucrose can harm an unborn baby if you have a severe reaction to this medicine during your second or third trimester. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This website is intended for use by US healthcare professionals only. And this type of reaction is possible even if you didnt have a reaction to your first dose of the drug. The use of Injectafer and Feraheme in treating IDA in these adults has been directly compared in a clinical study. The following lists contain some of the key side effects that may occur while taking Injectafer. Always review your medical history with the treatingphysician. However, diarrhea it isnt very common in people using Injectafer. Together, you and your doctor can develop a treatment plan thats best for you. (IV iron is absorbed by the body more rapidly than oral iron.) Side effects from HRT depend on a number of factors: Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. These effects typically last between 7 and 11 hours. I hope you found answers and are feeling better now. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. WebMD does not provide medical advice, diagnosis or treatment. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. It will take about three weeks to feel the effects but your fatigue will disappear and you will feel like a new person. Knowing how longside effectslast can help with the decision on whether to use a particulardrug. People with IDA have low blood levels of hemoglobin. If you have questions about using Injectafer in a child, talk with your doctor. Your doctor will determine the best dosage to fit your needs. Data on file, American Regent, Inc. 1. Before taking Injectafer, be sure to tell your doctor or pharmacist about any medications you take, including any over-the-counter vitamins or supplements. Youll receive doses of either drug by a healthcare professional at a medical facility. This medication passes into breast milk. Their medical staff can help you set up another time to receive your Injectafer dose. On day three I had a headache and felt heavy/exhausted, which lasted a few days. No, you most likely wont take Injectafer long term. Hes an expert in genetic testing, genetic analysis, andprecision medicine. However, there has been a report of delayed allergic reaction in someone receiving a second dose of Injectafer. Common Venofer side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting, diarrhea; muscle or joint pain, back pain; pain or swelling in an arm or leg; itching; or bruising or irritation where the medicine was injected. But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Low iron saturation, or iron deficiency, has various possible causes. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. I used to get a different type but my . It belongs to a class of medications called iron replacement products. fluid retention, especially in your arms, legs, or feet, people who took Feraheme had their hemoglobin level increase, on average, by 1.38 grams per deciliter (g/dL), people who took ferric carboxymaltose had their hemoglobin level increase, on average, by 1.63 g/dL, having strange cravings to eat items that arent food, such as ice, people who took Injectafer had their hemoglobin level increase, on average, by 1.6 grams per deciliter (g/dL), people who kept taking iron by mouth had their hemoglobin level increase, on average, by 0.8 g/dL, people who took Injectafer had their hemoglobin level increase, on average, by 2.9 g/dL, people who took the other intravenous iron product had their hemoglobin level increase, on average, by 2.2 g/dL, people who took Injectafer had their hemoglobin level increase by an average of 1.1 g/dL, people who took Venofer had their hemoglobin level increase by an average of 0.9 g/dL, cannot tolerate or have shown a poor response to oral iron, or, have been diagnosed with chronic kidney disease (CKD) that is non-dialysis dependent. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Side effects are uncomfortable reactions to medications or drugs. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. Talk with your doctor. Following an LSD trip, users may experience a sort of 'comedown.'. Typical Injectafer doses for iron deficiency anemia (IDA) depends on your body weight. With slow IV injection, the drug is given as a single, slow injection into your vein. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. Keep all drugs in a safe place. ByDr. This document does not contain all possible drug interactions. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. Headache. And this can lead to anemia, including IDA. You may report side effects to FDA at 1-800-FDA-1088. The researchers looked to see how well each drug worked to increase peoples hemoglobin level. The Role of Genetics in Multifactorial Disorders, The Power of DNA Testing and Predictive Medicine, A Guide to Genome Explorer (Free Version), Whole Genome Sequencing in As Little As Three Weeks, What Diseases Can Be Detected Through Genetic Testing, Breast Cancer Genetic Testing: Pros and Cons, At Home Genetic Testing for Breast Cancer, DNA Tests for Breast Cancer Genetic Testing, What to Do When Medicines Have Side Effects, Blood Type and COVID: Infection Risk and Severity, Where Can I Get My Blood Type Checked for Free, How to Find Biological Father Through DNA. Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. Its possible to get rid of or reduce the severity ofside effects. We cancelled my 5th because of the reaction. If you have diarrhea while youre taking Injectafer, call your doctor. But you dont necessarily need to eat these foods unless your doctor tells you to do so. This is only a brief summary of general information about this medicine. But if they become more severe or dont go away, talk with your doctor or pharmacist. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. Last updated on Feb 20, 2023. (A class of medications describes a group of drugs that work in the same way.). Can diet help improve depression symptoms? And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. People who are ongoingcancer treatmentwithradiation therapyor takingchemotherapy drugsmay be more susceptible toside effects. <> This includes your doctors, nurses, pharmacists, and dentists. If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. Notify your healthcare provider of all medical conditions and any medications, including supplements you are taking. In fact, Injectafer is meant for some people whose anemia didnt improve with iron pills or for people who had side effects from iron pills. Then your body uses that iron to make hemoglobin and RBCs. These lists contain examples of serious side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Why is the range so wide? One study of just under 5000 HRT users found that 43% were affected. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. experience severe side effects, please seek medical attention right away and notify the ordering physician. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Reactions around the injection/infusion site, such as pain, irritation, itching, bleeding, or discoloration after leakage of injection into the skin. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. The drug helps increase your hemoglobin level back to a value thats within the normal range. Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. This allows them to manage any side effects that you may have following your dose. For some people, it may be OK to continue taking a multivitamin that contains iron. Injectafer and Venofer have different approved uses, but theyre both used to treat IDA in people with CKD. Nose or throat irritation. However, many people have no side effects or only have minor side effects. Do not start, stop, or change the dose of any drug without checking with your doctor. And this could lead to weight gain, if they increase their food intake. But you kidneys need iron in order to make EPO. Severeside effectsmay end up causing a lot of disruption in a persons life. What Is the Cost of Whole Genome Sequencing (WGS)? It is important to get each dose of this medication as scheduled. stream Best food forward: Are algae the future of sustainable nutrition? Brand-name medications usually cost more than generics. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. There are 2 tests that your doctor will likely
Answer by DrLact: About Venofer usage in lactation. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). This is not a complete list of side effects and others may occur. A healthcare provider will give you this injection. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. A boxed warning is the most serious warning the Food and Drug Administration (FDA) can issue about a drug. And Feraheme is approved for use in adults who have CKD who may or may not need dialysis. They can give you tips on how to deal with any side effects that may be bothersome. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. monitor along with your hemoglobin and red blood cell count: The Venofer patient brochure provides information and support for CKD patients (2 years and older) with IDA. 2023 Medicine.com All rights reserved. After getting one treatment course of Injectafer, you typically wont need another dose of the drug again unless your anemia comes back. In pediatric patients the most common side effects (>2%) are headache, viral respiratory tract infection, peritonitis, upset stomach, throwing up, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension and hypertension (increased blood pressure). signs of inflammation in the lining of your stomach - pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. Understanding what thoseside effectsare can lead to a strategy to prevent them. Click below for effective ways to alleviate the discomfort felt fromside effects and learn how to get a free Medication and Drug Reaction DNAReport. This website is intended for use by US patients. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Once inside your body, ferric carboxymaltose releases iron into your system. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Consult the product instructions and your pharmacist for storage details. If these effects continue or worsen, tell your doctor. Excessive amounts of Venofer may lead to a condition called iron overload, which may be harmful. Hemoglobin is a protein thats found inside your red blood cells. How long it takes for the bodyto break down the meds matters and some peoples bodies simply take longer than others. If you have questions about using Injectafer for anemia during pregnancy, talk with your doctor. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. People from different ethnic backgrounds process medications differently. Suffering from somemedical conditionsput people at risk fordrugside effectsof medications for other health concerns. In clinical studies, people who took Injectafer still had iron in their system that was released by the drug 24 days after theyd gotten their injection. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Generic name: iron sucrose (injection) [EYE-urn-SOO-krose] But in some people, Injectafer can cause symptoms of hypophosphatemia to occur. During pregnancy, this medication should be used only when clearly needed. To learn about other mild side effects, talk with your doctor or pharmacist, or see Injectafers package insert. Its given by either intravenous (IV) infusion or slow IV injection. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. . Or your doctor may recommend that you change your eating habits to include more iron in your diet. Do not share your drugs with others and do not take anyone else's drugs. In order for your body to make RBCs, your bone marrow needs a hormone called erythropoietin (EPO). fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022, Iron is also necessary for your bone marrow to build healthy new red blood cells and provide oxygen to your organs and tissues through hemoglobin, If you or your child has been prescribed Venofer, its based on your blood work, which shows how many red blood cells you have and whether you have enough iron in your blood cells, If you are iron deficient, raising your iron levels can help increase your hemoglobin levels, Treating your anemia may help prevent future health problems, Over time, untreated IDA can cause heart problems; if you already have heart problems, it can make those problems worse, Venofer is given intravenously (through an IV) and
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Canada residents can call a provincial poison control center. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. When the toxins are released into the air, they can be inhaled and cause irritation to the lungs. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. (Hemoglobin is a protein thats found in your red blood cells.). There have also been reports of serious allergic reactions to Venofer. This medication is given by injection into a vein as directed by your doctor. other treatments you receive, you will need to go back for several treatments with Venofer. Below are examples of these side effects. Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. Youll receive doses of Injectafer from a healthcare professional at a medical facility. With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. Cardiovascular health: Insomnia linked to greater risk of heart attack. Iron is also necessary for your bone marrow to build healthy new red blood cells and provide oxygen to your . All of the people took iron by mouth for 2 weeks. Innovators Monograph Have blood work checked as you have been told by the doctor. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. If needed, theyll recommend treatment, including certain medications. Most people do not know how long theirside effectswill last until they go through them. *Patients are calculated based on an estimated annual cumulative dose. But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. Undergoingcancer treatmentwithradiation therapyorchemotherapy drugsmay result inhair loss, which can be devastating to somepeople. There isnt a known interaction between Injectafer and alcohol. fever. Effectiveness of Injectafer compared with iron thats taken by mouth. This is not a complete list of side effects and others may occur. And the drug has also been studied in children with IDA who have inflammatory bowel disease (IBD). Its not known how often people taking a treatment other than Injectafer had diarrhea. For additional information, contact your healthcare provider. This is because alcohol reduces your bodys absorption of certain nutrients that are necessary to make red blood cells. Brandon ColbyMD, a medical expert specializing in preventive medicine and clinicalgenomics. Examples of other drugs that may be used to treat IDA include: Your doctor will recommend the drug thats right for you depending on the severity of your anemia and any other medical conditions you may have. The rest of the people switched from taking iron by mouth to taking an iron product other than Injectafer thats given by IV. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. If you notice other effects not listed above, contact your doctor or pharmacist. You will be watched closely for at least 30 minutes to make sure you do not have an allergic reaction. But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. All rights reserved. Patients with celiac disease (gluten intolerance). Side effects like nausea and low blood pressure are common with most iron infusions. After receiving IV iron therapy, you will be monitored for 30 minutes to make sure you do not have an allergic reaction or a drop in blood pressure. Here's some detail on certain side effects this drug may cause. This gives a total cumulative dose of 1,500 mg of Injectafer. To make sure Venofer injection is safe for you, tell your doctor if you have: hemochromatosis or iron overload (the buildup of excess iron). There are different types of anemia, but IDA is the most common type. For more information on the possible side effects of Injectafer, talk with your doctor or pharmacist. Learn how to store and discard medical supplies safely. Many patients with kidney disease cannot get enough iron from food and require injections. Weight changes may be due to symptoms of anemia improving. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. Does Venofer Vial interact with other drugs you are taking? For people weighing 50 kg (about 110 lb) or more, administer Injectafer in two doses of 750 mg, at least 7 days apart. Although a single administration of FCM frequently causes transient hypophosphatemia, a 2016 study showed that repeated treatment with FCM is associated with a high risk of developing severe and prolonged hypophosphatemia and should therefore be monitored. Generics tend to cost less than brand-name drugs. Follow your doctor's directions carefully. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Venofer. Seriousside effectsshould be reported to a physician and/orPharmDfor medical advice. WARNINGS/CAUTIONS: Serious hypersensitivity reactions, including anaphylactic-type reactions (itching, hives, swelling, wheezing, difficulty breathing, fainting and/or other allergy symptoms), some of which have been life threatening and fatal, have happened in patients receiving Venofer. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Drug interactions may change how your medications work or increase your risk for serious side effects. chest pain. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl. MNT is the registered trade mark of Healthline Media. upper respiratory infection. This survey is being conducted by the WebMD marketing sciences department. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Use of the term female in this article refers to sex assigned at birth. 2. Tell your doctor if you are taking iron supplements or other iron-based oral medications. A lack of iron can lead to iron deficiency anaemia if left untreated. Review our medical disclaimer. You will need frequent medical tests to help your doctor determine how long to treat you with Venofer. Follow all instructions closely. Storage Condition Store in a cool and dry place protected from light. Check with your pharmacist if you have questions about the best way to throw out drugs. You would receive 15 mg of Injectafer per kilogram of body weight for each of your two doses. Infusion times range from less than 20 minutes to up to 4 hours. How is Venofer (iron sucrose) given? Not all possible drug interactions are listed here. . Consult your doctor before breast-feeding. Venofer is used to treat iron deficiency anemia in people with kidney disease. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. endobj Other drugs are available that can treat iron deficiency anemia (IDA). But its not known whether this poses any risk to a child whos breastfed. So we cant say for sure whether the drug is safe to use while youre pregnant. Injectafer and Venofer are both brand-name drugs. Symptoms of overdosage include drowsiness, mental confusion, dizziness, diarrhea and vomiting etc. Learn more about the types of tests and treatment. The following information is provided for clinicians and other healthcare professionals. What is the latest research on the form of cancer Jimmy Carter has?
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